The New England Journal

Metformin for the Treatment of the Polycystic Ovary SyndromeMetformin increases insulin sensitivity and may reduce the risk of diabetes. In the polycystic ovary syndrome, long-term metformin treatment may increase ovulation, improve menstrual cyclicity, and reduce serum androgen levels.


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Major Depressive DisorderThis review of major depressive disorder is a comprehensive account of the genetic, biochemical, and neurophysiological changes that have been implicated in the disorder.

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B-Cell IdentityAblation of the transcription factor Pax-5 results in the dedifferentiation of B cells in mice. Some of these dedifferentiated cells redifferentiate into functional T cells.

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